Sedation & sleep

Sleep (PRN)

GenericBrandRouteDoseNotes
ZolpidemStilnoxPO5–10 mg nocteZ-drug; short-term only
MelatoninPO2 mg noctePreferred in elderly / delirium risk

Acute agitation / sedation

GenericBrandRouteDoseNotes
HaloperidolHaldolPO / IM / IV0.5–2 mg, repeat cautiouslyDelirium / agitation; QT, EPS; avoid in Parkinson’s / Lewy body
LorazepamAtivanPO / IM / IV0.5–1 mgAgitation, alcohol withdrawal, seizures
DiazepamValiumPO / IV / PR2–10 mgSeizures, alcohol withdrawal; long-acting
MidazolamDormicumIV / IM / buccal2–5 mg IV titrated; 10 mg buccalShort-acting; respiratory depression — monitor

Try verbal de-escalation and treat the cause of delirium first. Use the lowest effective dose; benzodiazepines can worsen delirium (reserve for alcohol/benzo withdrawal or seizures).

Educational reference for clinicians. Doses are typical adult starting points — cross-check current local policy, the formulary, and renal/hepatic function before prescribing. Last reviewed: July 2026.

Last reviewed · July 2026

MOC