Cardiovascular medications

Which drug?

IndicationFirst-lineCaution
Uncomplicated HTNACEi/ARB, CCB, or thiazide-like diuretic (consider patient factors)
HFrEFGuideline-directed: ARNI (or ACEi/ARB) + evidence-based BB + MRA + SGLT2iAvoid non-DHP CCBs (verapamil, diltiazem): negative inotropic
CKD + albuminuriaACEi/ARB
PregnancyLabetalol; nifedipine MR. Methyldopa is an alternativeACEi, ARB, MRA contraindicated
AF rate controlBB or non-DHP CCB (diltiazem, verapamil) where appropriateAvoid non-DHP CCBs in HFrEF

Antihypertensives

ClassMedication (Brand)Dose
ACE inhibitorLisinopril (Zestril)5–20 mg OD
Ramipril (Tritace)1.25–10 mg OD
Perindopril (Coversyl)2–8 mg OD
Captopril (Capoten)12.5–50 mg BD or TDS
ARBValsartan (Diovan)80–160 mg OD
Telmisartan (Micardis)20–80 mg OD
Candesartan (Atacand)8–32 mg OD
CCB (DHP)Amlodipine (Norvasc, Istin)5–10 mg OD
Nifedipine LA (Adalat LA)30–60 mg OD
Lercanidipine (Lercadip)5–20 mg OD
Thiazide-like diureticIndapamide (Natrilix)1.25–2.5 mg OD
Loop diureticFurosemide (Lasix)HTN/oedema: 20–80 mg PO / IV
Aldosterone antagonistSpironolactone (Aldactone)25–100 mg OD
Beta blockers (also anti-anginal / rate control)Bisoprolol (Concor)2.5–5 mg OD
Metoprolol (Lopressor)50–100 mg BD
Carvedilol (Dilatrend)6.25–25 mg BD
Atenolol (Tenormin)25–100 mg OD–BD
Labetalol (Trandate)100–400 mg BD
Central acting agentMethyldopa (Aldomet)250–500 mg BD / TDS
Direct vasodilatorHydralazine (Apresoline)100–200 mg/day in 3–4 divided doses
CombinationAmlodipine + Valsartan (Exforge)5/160, 10/160 mg OD
CombinationExforge HCT (+ Hydrochlorothiazide)5/160/12.5, 10/160/12.5 mg OD
CombinationAmlodipine + Telmisartan (Twynsta)40/5, 80/5, 80/10 mg OD
CombinationAmlodipine + Perindopril (Coveram)5/5, 5/10, 10/10 mg OD
CombinationTelmisartan + HCTZ (Micardis Plus)80/12.5 mg OD
CombinationValsartan + HCTZ (Co-Diovan)80/12.5, 160/25 mg OD

Anti-anginal

ClassMedication (Brand)DoseNotes
Long-acting nitrateIsosorbide mononitrate (Monorem, Imdur)30–60 mg ODKeep a nitrate-free interval; headache
Short-acting nitrateGTN (glyceryl trinitrate)SL 0.4–0.5 mg PRN; IV infusion for ACS / pulmonary oedemaAvoid if hypotensive or recent PDE5 inhibitor
MetabolicTrimetazidine (Vastarel MR)35 mg BDAdd-on
MetabolicRanolazine (Ranexa)375–750 mg BDQT prolongation
If-channel inhibitorIvabradine (Procoralan)5–7.5 mg BDSinus rhythm, HR ≥ 70
K-channel activatorNicorandil10–20 mg BDConfirm local availability

First-line anti-anginals are beta blockers and CCBs (see above); agents here are add-on or alternatives.

Anti-arrhythmic

Drug (Brand)DoseUse / notes
Amiodarone (Cordarone)Arrest: 300 mg IV bolus. Non-arrest: 300 mg IV over 20–60 min → 900 mg / 24 h; PO load 200 mg TDS then taperBroad (AF, VT); thyroid / lung / LFT monitoring; central line for infusion
Adenosine (Adenocor)6 mg rapid IV push → 12 mg → 12 mgSVT; transient; warn flushing / chest tightness; continuous ECG
Digoxin (Lanoxin)Load 500 mcg, then 250 mcg to ~1 mg / 24 h; maintenance 62.5–250 mcg ODRate control in AF; renal dose, check levels
Verapamil (Isoptin)IV 5–10 mg slow; PO 40–120 mg TDSRate control; avoid in HFrEF and with IV beta blocker
Flecainide (Tambocor)50–150 mg BD (or IV)AF cardioversion; only if structurally normal heart

Educational reference for clinicians. Doses are typical adult starting points. Cross-check allergies, interactions, current local policy, the formulary, and renal/hepatic function before prescribing.

Last updated · August 2026