Post-ROSC · adult ALS
Post-Resuscitation Care
The first 24 hours after ROSC — stabilize, identify the cause, and prevent re-arrest.
stabilize → examine → investigate → monitor → communicate
Step 1
Immediate priorities
- Stabilize circulation & prevent re-arrest
- Identify and treat reversible causes
- Temperature control
- Aggressive cooling to 33 °C is no longer routinely recommended
- Maintain core temperature ≤ 37.5 °C
- Use antipyretics and surface cooling if needed
- Monitor temperature closely during the first 72 hours
- History: obtain from staff, witnesses, or medical notes
- Key reversible causes to consider
- Myocardial infarction
- Hypoxia, hypoglycemia
- Stroke, overdose, electrolyte imbalance
- Trauma, pulmonary embolism, sepsis
- Documentation
- Duration of arrest
- Timeline of interventions and drug doses
Step 2
Initial stabilization
Circulation
- Establish rapid IV / IO access
- Give 1–2 L isotonic crystalloids if preload responsive
- Avoid excess fluids in CHF / pulmonary edema
- Initiate vasopressors early if hypotensive
- Norepinephrine is first-line
If recurrent VT / VF
- Follow ACLS algorithm
- Consider amiodarone or lidocaine
- Escalate to ECMO or PCI if refractory
Airway & breathing
- If intubating, use reduced sedation doses
- Avoid hyperventilation
- Target SpO₂ > 94 %, PaCO₂ 40–50 mmHg
Step 3
Clinical examination
- Confirm bilateral ventilation
- Check for rib fractures
- Assess for new murmurs, JVP
- Rule out aneurysm, peritonitis
- Perform baseline neuro exam
- Assess brainstem reflexes: pupils, corneal, gag & cough
- Asymmetry may suggest a stroke or structural lesion
- Avoid early prognostication — findings may improve
Tubes & lines
- Convert emergency lines to a central line (sterile)
- Insert urinary catheter
- Consider NG tube if unconscious
Step 4
Immediate investigations
- ECG: STEMI, arrhythmias, QTc, signs of PE
- ABG: mixed acidosis is common
- May improve with oxygen and perfusion
- Consider bicarbonate if severe
- CXR: confirm ETT placement +/− NGT & rule out pneumothorax
- Labs
- CBC, coagulation, troponin, electrolytes & lactate
- Repeat Q6H early on
- Toxicology screen if relevant
- Bedside Echo to assess regional wall-motion abnormalities
- CT head to rule out central causes
Step 5
Monitoring
- Continuous cardiac monitoring
- Head of bed at 30°
- Maintain glucose 7.8–10 mmol/L
- Use EEG monitoring if needed
- Treat seizures & myoclonus with sedation and anticonvulsants
- Consider empiric antibiotics if aspiration is suspected
Step 6
Family communication
- Provide clear & realistic updates
- Explain clinical status and potential outcomes
Reference
Related links
Last reviewed · May 2026