Clinical guide
Approach to ECG Interpretation
Step 1
Setup
- Patient name, date, time of recording
- Paper speed: 25 mm/s
- Calibration: 10 mm/mV
- Check lead placement and rule out artifacts
Step 2
Rate
- Normal: 50–100 bpm
- Regular rhythm
- use the 300 rule: 300 / number of large squares between two R waves
- Irregular rhythm
- count the number of R waves in a 10-second strip and multiply by 6
- Escape rhythms
- atrial: 60–80 bpm
- junctional: 40–60 bpm
- ventricular: 20–40 bpm
Step 3
Rhythm
- Regular vs. irregular vs. irregularly irregular
- Identify the P wave before every QRS and the QRS after every P wave
- Sinus rhythm: P upright in leads I, II, and aVF + rate 50–100 bpm
- Irregularly irregular = think AFib
Step 4
Axis
- Look at leads I and aVF:
- lead I +, aVF + → Normal axis
- lead I +, aVF − → Left axis deviation (LAD)
- lead I −, aVF + → Right axis deviation (RAD)
- lead I −, aVF − → Extreme axis
- Normal axis: −30° to +90°
Step 5
Intervals
- PR interval: 120–200 ms (3–5 small squares)
- QRS duration: ≤120 ms
- QT interval:
- use Bazett’s formula for QTc
- normal: <440 ms (men), <460 ms (women)
Step 6
P wave
- Left atrial enlargement (LAE)
- bifid P wave in lead II
- biphasic P in V1 (terminal negative portion >1 mm)
- Right atrial enlargement (RAE)
- tall, peaked P waves in II and V1 (>2.5 mm)
Step 7
QRS
- Bundle branch blocks (BBB)
- LBBB: broad, notched R in V5/V6; deep S in V1
- RBBB: rsR’ in V1; wide S in V6
- LVH criteria
- S in V1 + R in V5 or V6 >35 mm
- RVH criteria
- RAD + R/S >1 in V1
Step 8
ST / T
- Ischemia: ST depression, T wave inversion (V1–V6)
- Infarction: ST elevation in the affected area
- Reciprocal changes in opposite leads
- T wave changes: hyperacute (early), inverted (later)
figures drawn for MOC. waveforms are schematic, not patient recordings.
Step 9
Q waves
- 1 small square wide
- 25% of R wave height
- Present in ≥2 contiguous leads
Step 10
Other patterns
- Electrolytes
- hyperK: tall T waves → sine wave
- hypoK: U waves, ST depression, long QT
- hypoCa: long QT; hyperCa: short QT
- Drugs: digoxin (scooped ST), antipsychotics (QT prolongation)
- Pre-excitation (WPW)
- short PR <120 ms + delta wave (slurred QRS upstroke), broad QRS
- irregular broad-complex tachycardia in WPW = pre-excited AF: avoid AV-nodal blockers (adenosine, verapamil, diltiazem, beta-blockers, digoxin), see palpitations
- Others
- Osborne J waves (hypothermia)
- diffuse ST elevation + PR depression (pericarditis)
Final step
Correlate
- Summarize: rate, rhythm, axis, intervals, major abnormalities
- Compare to previous ECGs
- Correlate with symptoms and clinical scenario
- For related cases, explore approach to palpitations and chest pain to connect ECG findings with real clinical decisions
References
Life in the Fast Lane, ECG Library
Huge, easy-to-navigate library with annotated ECG examples and clinical pearls.
litfl.com/ecg-libraryECG Waves, Clinical ECG Interpretation
Detailed step-by-step explanations, beautiful visuals, and case examples.
ecgwaves.comGeeky Medics, ECG Interpretation Guide
Concise and OSCE-friendly; great for beginners and quick refreshers.
geekymedics.com/how-to-read-an-ecgAmerican Heart Association, ECG-related guidelines
Searchable hub for official ECG-related guidance (STEMI, blocks, arrhythmias). Tip: search “ECG” or “STEMI criteria”.
ahajournals.org
See also: MOC+ Volume 2: Cardiopulmonary, covers ACS, arrhythmias, and the ECGs that pin them down.
Last clinically reviewed · June 2026 · Last updated · September 2026